Dissociated Renin – Aldosterone Response to Acute Sodium Depletion in Patients with a Previous History of Pregnancy – Associated Hypertension

Abstract
The effect of Na depletion on body weight, plasma renin activity (PRA) and plasma aldosterone concentration was studied in 10 normotensive subjects with a previous history of pregnancy-associated hypertension. An appropriate increase in PRA, but a suppression of plasma aldosterone response to this form of acute Na depletion was demonstrated. The significance of this dissociated renin-aldosterone response is discussed.