A Non-hypophyseal Sex Difference in Estrous Behaviour of Mice Bearing Pituitary Grafts.

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Abstract
Summary Estrous behaviour in hypophy-sectomized female and male mice bearing hypophyseal grafts has been studied. The results were: (1) Hypophysectomized female mice bearing either female or male hypophyseal grafts, showed complete and normal estrous cycles. (2) Castrated males bearing ovarian and vaginal grafts showed a continuous noncyclic type of vaginal stimulation regardless of whether they had been grafted with male or female pituitaries. (3) The characteristic cyclic function of the female hypophysis may be related to the cyclic function of some other controlling structure rather than being dependent upon the pituitary gland itself.