Alkaline Phosphatase in Women with Osteoporosis

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Abstract
Partially independent measurements of bone mass (15) in 100 women with clinical and roentgenological signs of osteoporosis were correlated to the alkaline phosphatase activities of the same individuals. There was a slight but significant negative correlation indicating an increasing alkaline phosphatase activity with decreasing bone mass. This correlation was not caused by age interaction. There was no correlation between alkaline phosphatase activity and clinical or morphological signs of osteomalacia. The changes could not be explained by fractures. Apparently a slight increase in the alkaline phosphatase activity in women with a more severe osteoporosis is related to bone resorption.