The Enduring Behavioral Changes in Rats with Experimental Phenylketonuria
- 1 January 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (1) , 21-25
- https://doi.org/10.1073/pnas.71.1.21
Abstract
The biochemical features of phenylketonuria have been reproduced in developing rat pups by administering to them a combination of p-chloro-DL-phenylalanine plus L-phenylalanine for the first 21 days after birth. During the treatment period, the experimental animals show delayed eye opening and decreased brain weight compared with controls given saline. Neuropathological examination of developing animals reveals deficient myelination and some inhibition of cerebellar maturation. When tested as adults, after a long recovery period, animals with phenylketonuria are hyperactive in activity wheels. Adult rats are deficient in reversing a position choice and demonstrate impaired performance in a Y-maze. Rats treated with p-chloro-DL-phenylalanine plus L-phenylalanine during the vulnerable period of rapid brain development thus have enduring behavioral changes that persist throughout life.Keywords
This publication has 17 references indexed in Scilit:
- Vulnerability of developing brain. VI. relative effects of foetal and early postnatal undernutrition on reflex ontogeny and development of behaviour in the ratBrain Research, 1971
- INCREASED CEREBRAL EXCITABILITY CAUSED BY p‐CHLOROPHENYLALANINE IN YOUNG RATSJournal of Neurochemistry, 1971
- A learning impairment associated with induced phenylketonuriaLife Sciences, 1970
- Use of p-chlorophenylalanine to induce a phenylketonuric-like condition in ratsNeuropharmacology, 1970
- Learning Impairment associated with Maternal Phenylketonuria in RatsNature, 1970
- Phenylalanine antimetabolite effect on development — I. Behavioral effects of , -4-chlorophenylalanine in the young ratLife Sciences, 1969
- Effect of Undernutrition on the Size and Composition of the Rat BrainJournal of Nutrition, 1968
- Peripheral vasoconstriction with epinephrine for selective fixation of the central nervous system by perfusionActa Neuropathologica, 1968
- Neuropathology of PhenylketonuriaJournal of Neuropathology and Experimental Neurology, 1966
- A CHEMICAL INVESTIGATION OF THE DEFECTS OF MYELINATION IN PHENYLKETONURIAJournal of Neurology, Neurosurgery & Psychiatry, 1962