Nosocomial Outbreak Caused by a Multiresistant Clone of Acinetobacter baumannii: Results of the Case-Control and Molecular Epidemiologic Investigations

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Abstract
Objective: To describe a nosocomial outbreak caused by multiresistant Acinetobacter baumannii. Design: Descriptive and case-control study. Antibiotic susceptibilities and pulsed-field gel electrophoresis (PFGE) of genomic DNA digested with SfiI and also with ApaI were used as markers of strain identity. Setting: A large medical school-affiliated hospital in the city of Houston, Texas. Results: During a 10-week period, A baumannii was isolated from 25 patients admitted to the intensive care unit (ICU). The attack rate was 14.3 per 100 ICU admissions. Case patients were intubated more frequently and for longer periods, and had longer ICU and hospital stays (P

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