PREVENTION OF EXPERIMENTAL HYPERPARATHYROIDISM BY MAGNESIUM AND POTASSIUM SALTS1
- 1 August 1958
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 63 (2) , 216-225
- https://doi.org/10.1210/endo-63-2-216
Abstract
Young, growing rats were treated with parathyroid extract and NaH2PO4. This treatmentproduced an unusually intense osteoclastic bone absorption. However, in animals which, in addition, received either MgCl2 or KC1, the bone destruction was diminished and, often, osteoblastic new-bone formation occurred. Still, the skeleton never became totally insensitive to the action of theparathyroid extract. On the other hand, the production by parathyroid hormone plus NaH2PO4 of pathologic calcium deposits in the heart and kidney was completely inhibited by the magnesium and potassium salts, at certain dose levels. It might have been thought that the protective effects of magnesium chloride and potassium chloride are merely due to some local interference with the absorption of the phosphate, which accentuates the action of parathyroid hormone. However, it could be shown that, even when NaH2PO4 is given subcutaneously (by the granuloma pouch technique), both MgCl2 and KC1 afford protection against parathyroid hormone overdosage. The protective effect of potassium and magnesium salts appears to be closely linked to the presence of an excess of phosphate.Keywords
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