USE OF A BAMHI POLYMORPHISM IN THE FACTOR-IX GENE FOR THE DETERMINATION OF HEMOPHILIA-B CARRIER STATUS
- 1 May 1986
- journal article
- research article
- Vol. 67 (5) , 1508-1511
Abstract
A BamHI polymorphism has been identified in the human factor IX gene. This polymorphism, which occurs in approximately 6% of X chromosomes, has been used to determine the carrier status of a female in a family with a history of hemophilia B. This family was uninformative for the previously reported Taql and Xmnl polymorphisms in the factor IX gene.This publication has 13 references indexed in Scilit:
- Characterization of bovine prothrombin mRNA and its translation productBiochemistry, 1984
- CHARACTERISATION AND USE OF AN INTRAGENIC POLYMORPHIC MARKER FOR DETECTION OF CARRIERS OF HAEMOPHILIA B (FACTOR IX DEFICIENCY)The Lancet, 1984
- CARRIER DETECTION BY DIRECT GENE ANALYSIS IN A FAMILY WITH HAEMOPHILIA B (FACTOR IX DEFICIENCY)The Lancet, 1984
- Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).Proceedings of the National Academy of Sciences, 1984
- Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.Proceedings of the National Academy of Sciences, 1983
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- MONOCLONAL-ANTIBODY TO AN EPITOPE ON THE HEAVY-CHAIN OF FACTOR-IX MISSING IN 3 HEMOPHILIA-B PATIENTS1983
- The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNACell, 1978
- Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.Proceedings of the National Academy of Sciences, 1978
- Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B.Journal of Clinical Investigation, 1977