Control of Lymphatic Pumping: Interest of Daflon 500 mg

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Abstract
Objective: To determine the effects of Daflon 500 mg on lymph flow, known to be modulated by lymph formation and contractility of the collecting ducts. Experimental design: The effect of Daflon 500 mg was investigated in vitro on isolated rings of sheep mesenteric lymphatics, at concentrations of 10-7 M and higher. In vivo, lymph flow was measured in unanaesthetized sheep before and after 5 days of administration of Daflon 500 mg at the oral dose of 10 mg/kg/day. Results: Daflon 500 mg significantly increased the frequency of spontaneous contractions in vitro, and in vivo increased the lymph flow when compared with pre-drug levels. Conclusion: It is suggested that Daflon 500 mg increases lymph flow under these conditions by stimulating the lymph pump directly, a result that is consistent with previous studies.