PLATELET INTERACTION WITH DAMAGED RABBIT AORTA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (2) , 194-200
Abstract
Accumulation of 51Cr-labeled washed rabbit platelets on the subendothelium of rabbit aortae following injury with a balloon catheter was measured. The amount of radioactivity associated with the damaged wall within 10 min of injury did not change appreciably during the following 24 h, indicating that little turnover of platelets on the injured vessel wall occurred. By injecting 51Cr-labeled platelets into rabbits at different times after injury, the reactivity of the exposed surface to newly injected platelets was estimated. Scanning electron microscopy showed a monolayer of platelets initially formed on the injured surface; the number of platelets associated with the surface decreased over a 7 day period. The amount of 51Cr associated with the injured vessel wall diminished during this period. The ability of the damaged surface to attract fresh platelets gradually decreased during the 7 days following injury. Platelet survival in rabbits was not significantly reduced by removal of the aortic endothelium (balloon catheter injury 66.3 .+-. 12.2 h, sham operated 72.1 .+-. 7.2 h, untreated controls 76.2 .+-. 3.8 h). In rabbits, platelet survival may not provide an estimate of endothelial injury in all circumstances.

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