CYTOLYSOMES AND MITOCHONDRIAL DEGENERATION

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Abstract
The livers of rats injected intravenously with Triton WR-1339 (400 mg/200 to 300 gm rat) constitute another instance in which cytoplasmic structures undergo digestion within membrane-delimited vacuoles. The presence of acid phosphatase activity in these vacuoles is demonstrated in electron micrographs of tissue fixed overnight in cold 4% formaldehyde - 1% CaCl2 - 5% sucrose, sectioned at 40 [mu] with a freezing microtome, incubated in the Gomori acid phosphatase medium containing sucrose, post-fixed in osmium tetroxide-sucrose, and embedded in Epon 812 for thin sectioning. Other cells in which such enlarged lysosomes, or cytolysomes, occurs are listed.