Apolipoprotein E allele frequencies in an Italian population: Relation to age and lipid profile

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Abstract
Apo E phenotype and plasma Tg, Chol, LDL- Chol, HDL- Chol and Apo B levels were determined in a sample of 228 healthy Italian subjects (124 men and 104 women) aged 18–93. The allele frequencies were: ε2=0.070; ε3=0.829; φ=0.101 (among the lowest values in the literature). Division of the sample into four age groups indicated that ε4 frequency decreased with age to 0 in persons aged over 75. Covariance analysis of the influence of each allele on plasma lipids showed that ε4 was significantly associated with the highest hol, LDL- Chol and Apo B levels. These data are evidence of the influence of ε4 on Chol metabolism in an Italian population. They also show that its frequency decreases with age.(Aging Clin. Exp. Res. 7: 185–189, 1995)

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