Synthesis and Antitumor Activities of Water-Soluble Benzoylphenylureas.
- 1 January 1999
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 47 (3) , 430-433
- https://doi.org/10.1248/cpb.47.430
Abstract
Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.Keywords
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