Effect of Chlorpropamide on Urinary Excretion of Water and Solute in Patients with Diabetes Insipidus and on Water Flow Across Isolated Toad Bladder1

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Abstract
Chlorpropamide, given intravenously (4 mg/kg) to 7 water-loaded patients with vasopressin-responsive diabetes insipidus, significantly reduced the urinary flow, free-water clearance and osmolal clearance; the creatinine clearance, urinary sodium excretion and urinary osmolal concentration were not significantly changed. In the isolated toad bladder chlorpropamide (3.3 mm) significantly increased the osmotic water flow across the membrane. The effect of increasing doses of the drug on the water flow suggested that the mechanism of action of chlorpropamide is saturable. The results suggest that chlorpropamide increases the osmotic permeability to water of both the distal nephron of patients with diabetes insipidus and the isolated toad bladder.

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