Zur Toxikologie des Dimetilan (Dimethylcarbamyl-methyl-pyrazolyl-(5)-dimethylcarbamat)

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Abstract
Dimetilan as cholinesterase inhibitor produces symptoms which are characteristic for this type of poison. Median lethal dose (LD50) on single administration by mouth: mouse, 63 mg/kg; rat, 64 mg/kg; guinea pig, 63 mg/kg. Rat, sub-chronic oral administration (once a day for 4 weeks): LD50 about 35 mg/kg/day. After 4 weeks at 20 mg/kg/day: no pathological changes in leucocyte-count or differential blood-picture; no abnormal macro-scopicfindings; no important histological changes. Rat, subchronic oral administration of doses increasing from 0.6 to 61 mg/kg/day: no cumulation, no development of tolerance. Rabbit eye: no local irritation in concentrations up to 0.5%. Rat, cutaneous toxicity: Single application : LD50 2000 mg/kg. Subchronic application (once a day for 4 weeks): LD50 2000 mg/kg/day; no local irritation, distinct resorptive toxicity. In the mouse the simultaneous intravenous administration of atropine sulphate or Parpanit or a suitable pre-treatment with pyridine-2-aldoxime-N-methiodide counteracts the toxic effects of dimetilan per os.

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