New .ALPHA.-amylase inhibitor, trestatins. I. isolation, characterization and biological activites of trestatins A, B and C.

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Abstract
A trestatin complex which exhibited a potent inhibitory activity on various .alpha.-amylases was isolated from the culture filtrate of Streptomyces dimorphogenes sp. nov. Three major components, trestatins A, B and C, were purified by adsorption and ion-exchange chromatography. Their spectral and chemical properties suggested that trestatins were novel basic oligosaccharide homologues each characterized by the possession of a trehalose moiety at the non-reducing end of the molecule.