THE HOST-PARASITE RELATIONSHIP IN TULAREMIA I. A

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Abstract
Chromatographic analysis of the blood of normal rats and rats infected with Bact. tularense showed that during infection there is a pronounced decrease of 12 free amino acids in the blood of the infected animals. Blood removed during routine procedures had no effect on the concn. of free amino acids in the blood of the rats. No change in the free amino acid levels in the blood was observed in rats which were inoculated with high concns. of killed cells of the Sm strain or with living avirulent organisms of strain 38. Upon recovery from infection with the highly virulent Sm strain, the concn. of free amino acids in the blood of the rats returned to normal within 25 days following infection. Normal concns. of the free amino acids remained unchanged in the blood of rats recovered from tularemia and reinfected after an interval of 30 days. Analysis of the urine of normal and infected animals showed the presence, in low concn., of 5-9 amino acids. No significant differences could be detected in the no. or concn. of these compounds in the normal and infected picture.