Biochemical studies of toxic agents. 9. The metabolic conversion of indence into cis- and trans-indane-1:2-diol

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Abstract
Indene was given to rabbits by stomach tube, and fractionation of ether extracts of the urine has yielded optically active cis- and trans-indane-l:2-diol in a total amount corresponding to about 5% of the dose. Acid treatment of the urine, either before or after ether extraction, yielded indan-2-one in amounts corresponding to about 25% of the dose of indene. The same two diols were isolated from the urine of rabbits dosed with indene by subcutaneous injection. cis-Indane-l:2-diol was isolated from ether extracts of the urine of rats dosed with indene by stomach tube. Indan-2-one was obtained by acid treatment of the extracted urine. The inter-conversion of cis- and trans-indane-l:2-diol was studied, and the metabolic formation of the two diols is discussed.