Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts

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Abstract
Modifications of cell shape induced in cultured newborn rat astroblasts by serum deprivation or dibutyryladenosine 3′–5′ monophosphate (dBcAMP) are described. Serum suppression modifies the adhesivity of the cells to the substrate, but this modification is not consistent with a true differentiation. The main ultrastructural feature of dBcAMP-treated astroblasts is the presence of an extensive system of 90 Å microfilaments, while control cells are relatively devoid of these structures.