The Cutaneous Reactivity of Guinea Pigs to Pure Protein Antigens

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Abstract
Guinea pigs sensitized with ovalbumin in complete adjuvant injected subcutaneously or into the footpads in incomplete adjuvant or intradermally in saline showed Jones-Mote reactions when skin tested 1 week later and Arthus reactions when skin tested 2 weeks later. The reactions on each occasion were of similar intensity in all groups of animals. Mixed Arthus and delayed-type hyper sensitivity resulted from sensitization with ovalbumin in complete adjuvant injected either subcutaneously or into the footpads. The delayed reactions were slightly less intense in animals injected subcutaneously. Maximal Arthus and delayed skin reactions occurred only in animals sensitized with ovalbumin emulsified in complete adjuvant. One or both components of the reactions were diminished in animals in which the adjuvant and ovalbumin were injected separately.

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