AN APPARENT SELECTIVE ACCUMULATION OF TESTOSTERONE BY HUMAN BREAST TISSUE

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Abstract
Folca, Glascock & Irvine (1961) showed that human breast tumours have the ability to concentrate radioactive hexoestrol in amounts greater than those found in blood and muscle. We have found that in some patients both normal and neoplastic breast tissues can also selectively accumulate radioactivity following administration of tritium-labelled testosterone. Five women with breast cancer were given between 2 and 6 μc. of testosterone-1, 2-3H (i.v.) 6 hr. before radical mastectomy. At operation, muscle, fat, normal breast and tumour tissue were obtained (and in some instances, blood, skin and lymph nodes also). The tissues were cut into small pieces and then homogenized in a blender with excess ether-ethanol (3:1). The extraction was repeated twice more and the combined ether-ethanol extracts taken to dryness. The residues were dissolved in 70% aqueous methanol and lipids removed by partition with petroleum ether. The aqueous methanol was taken to dryness, the residues

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