The Hypothalamic-Pituitary Axis

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Abstract
Testing of hypothalamic-pituitary-end-organ function has advanced remarkably in recent years. As newer tests are compared to the standard ones, it has become apparent that no single test can determine overall normality of glandular function, that each specific technic gives information only about a particular facet of a gland's function. Thus, the paper by Martin et al. in this issue reports significant dissociation between two tests of hypothalamic-pituitary-adrenal function. Impairment of the stress mechanism was present in several subjects while they had intact metyrapone responsiveness. Similarly, subjects had an adequate growth-hormone response to insulin, but a deficient cortisol response. Of obvious . . .

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