Properties of amiodarone monolayer spread at the air–water interface
- 1 August 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (8) , 561-566
- https://doi.org/10.1111/j.2042-7158.1986.tb03081.x
Abstract
Surface pressure measurements demonstrate that, over a wide range of pH, amiodarone forms a stable monolayer at the air–water interface. The area found to be occupied by an amiodarone molecule was compared with a theoretical prediction based on a conformational analysis, making it possible to assemble amphiphilic molecules. The intrinsic ionization constant of amiodarone in an aqueous environment pKi = 8.7 ± 0.5 was evaluated from surface potential measurements.This publication has 6 references indexed in Scilit:
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