Effects of Propranolol on Several Physiological Responses During Orthostatic and Exercise Stress in Healthy Male Subjects
- 1 October 1971
- journal article
- clinical trial
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 49 (10) , 867-872
- https://doi.org/10.1139/y71-121
Abstract
The effects of propranolol administration on several responses to orthostatic and exercise stress were examined in 16 healthy young men. Propranolol treatment resulted in a significantly lower heart rate response to orthostatic stress, while systolic and diastolic blood pressures were unaffected by the drug. Propranolol treatment resulted in a significant reduction in heart rate and minute ventilation during bicycle exercise. However, oxygen consumption and mean exercise endurance times were not significantly altered following propranolol treatment. The findings suggest that in healthy young male subjects the cardiac depressant effects of propranolol are compensated for, so that the oxygen uptake and work capacity are not seriously compromised.Keywords
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