Influence of the peptide chain length of new elongated tuftsin analogs on phagocytosis process

1 September 1984

journal article
research article
Published by Wiley in International Journal of Peptide and Protein Research

Vol. 24 (3) , 267-273
https://doi.org/10.1111/j.1399-3011.1984.tb00953.x

Abstract

In this paper the synthesis of the following elongated tuftsin analogs: Arg‐Thr‐Lys‐Pro‐Arg (1), Pro‐Arg‐Thr‐Lys‐Pro‐Arg(II), Lys‐Pro‐Arg‐Thr‐Lys‐Pro‐Arg(III) and Thr‐Lys‐Pro‐Arg‐Thr‐Lys‐Pro‐Arg(IV) by classical and solid‐phase methods are described. The obtained peptides were tested for their biological activity: restoration of the phagocytosis of defected granulocytes from blood of children with acute lymphoblastic leukemia (ALL).

Keywords

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