Assay of Serum Vitamin B12 Concentration Using Co57-B12 and Intrinsic Factor
- 1 October 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 108 (1) , 45-48
- https://doi.org/10.3181/00379727-108-26840
Abstract
Based on some observed properties of the B12-intrinsic factor complex, an assay procedure is described for determining serum Vit. B12 levels using isotopically labeled Vit. B12 and intrinsic factor. Eighty-three-112% of crystalline Vit. B12 added to serum was recovered in the assay. Concentrations of Vit. B-12 deficient, and leukemic sera were in the ranges, 104-328 [mu][mu]/ml, 0-72 [mu][mu]g/ml and over 1000 [mu][mu]g/ml respectively.Keywords
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