Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration
- 1 January 1987
- journal article
- conference paper
- Published by Springer Nature in Acta Neuropathologica
- Vol. 73 (2) , 131-137
- https://doi.org/10.1007/bf00693778
Abstract
Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29±19 mm3 (mean±SD) versus 58±35 mm3,P3), and increased in chronic diabetes (91±22 mm3,P<0.0463). The cortex adjacent to the infarct showed selective neuronal injury affecting the cortical layers 2 and 3. The damage was enhanced by hypoglycemia and prevented in most of the diabetic animals. The findings indicate that different mechanisms cause infarction and selective neuronal injury outside infarcts, but that both are influenced by the plasma glucose concentration.Keywords
This publication has 28 references indexed in Scilit:
- Autoradiographic Determination of Cerebral Glucose Content, Blood Flow, and Glucose Utilization in Focal Ischemia of the Rat Brain: Influence of the Plasma Glucose ConcentrationJournal of Cerebral Blood Flow & Metabolism, 1988
- Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [14C]2-Deoxyglucose PhosphorylationJournal of Cerebral Blood Flow & Metabolism, 1986
- Focal Ischemia of the Rat Brain: Autoradiographic Determination of Cerebral Glucose Utilization, Glucose Content, and Blood FlowJournal of Cerebral Blood Flow & Metabolism, 1986
- Recirculation in the Rat Brain following Incomplete IschemiaJournal of Cerebral Blood Flow & Metabolism, 1983
- Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitusThe American Journal of Medicine, 1983
- Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery OcclusionJournal of Cerebral Blood Flow & Metabolism, 1981
- Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization.Stroke, 1980
- VARIATIONS IN THE HUMAN PURKINJE CELL POPULATION ACCORDING TO AGE AND SEXNeuropathology and Applied Neurobiology, 1975
- Temporary Occlusion of the Middle Cerebral Artery in the Monkey: Clinical and Pathological ObservationsStroke, 1970
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946