Relation between end-diastolic pressure and mean rate of ejection of left ventricle

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Abstract
The relation between end-diastolic pressure (LVEDP) and mean rate of ejection (MRE) of the left ventricle was investigated in an areflexic dog right heart bypass preparation. An increase in stroke volume from 10. 4 to 30. 8 ml gained by increasing ventricular inflow increases LVEDP and MRE. Increasing heart rate from 113 to 196/min causes no change in LVEDP and increases MRE. An increase in aortic pressure from 58 to 120 mm Hg causes little or no change in LVEDP with an increase in MRE. A higher increase in aortic pressure causes an increase in LVEDP and a decrease in MRE. Abnormal activation of the left ventricle causes an increase in LVEDP with no change in MRE. Infusion of norepinephrine or administration of acetyl strophan-thidin decreases LVEDP and increases MRE. Thus many factors influence the relation between end-diastolic pressure and mean rate of ejection of the left ventricle. It is important to control these factors when this relation is used to indicate a change in performance characteristics of the left ventricle.

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