How is rat liverS-adenosylmethionine synthetase regulated?
Open Access
- 31 August 1992
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 309 (1) , 1-4
- https://doi.org/10.1016/0014-5793(92)80726-w
Abstract
The in vivo regulation of S‐adenosylmethionine synthetase, a key enzyme in methionine metabolism, is so far unknown. The enzyme activity has been shown to be modulated by glutathione and the oxidation state of its sulfhydryl groups. Analysis of the protein sequence has revealed the presence of putative phosphorylation sites. A mixed regulatory mechanism combining phosphorylation and the oxido/reduction of sulfhydryl groups is proposed. The role of glutathione in this mechanism is also discussed.Keywords
This publication has 14 references indexed in Scilit:
- Analysis of the 5′ non‐coding region of rat liver S‐adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzymeFEBS Letters, 1991
- The role of cysteine-150 in the structure and activity of rat liver S-adenosyl-l-methionine synthetaseBiochemical Journal, 1991
- Methionine metabolism in mammalsThe Journal of Nutritional Biochemistry, 1990
- Inactivation and Dissociation Of S –Adenosylmethionine Synthetase by Modification of Sulfhydryl Groups and Its Possile Occurrence in CirrhosisHepatology, 1990
- Conversion of rat liver synthetase from high-Mr form to low-Mr form by LiBrBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1988
- S -adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosisHepatology, 1988
- Purification and comparison of two forms of S‐adenosyl‐l‐methionine synthetase from rat liverEuropean Journal of Biochemistry, 1987
- Isozymes of S-Adenosylmethionine Synthetase from Rat Liver: Isolation and Characterization1The Journal of Biochemistry, 1986
- Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterizationBiochemistry, 1981
- Biological Methylation: Selected AspectsAnnual Review of Biochemistry, 1975