IONIZED CALCIUM AND MAGNESIUM IN BABOON - HEMORRHAGIC-SHOCK AND RESUSCITATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 5  (2) , 163-172
Abstract
Ca2+ and Mg2 + are important intracellular messengers and control excitation-contraction coupling excitation-section coupling, oxidation phosphorylation and mitochondrial acid-base balance. This study examines the effect of hemorrhagic shock on serum Ca2+ and Mg2+. Eight baboons were subjected to severe hemorrhagic shock and then resuscitated. Ca2+ was measured by the Orion SS-20 flowthrough Ca electrode and Mg2+ was calculated by the method of Killen. Other measurements included: total Ca, bound Ca, total Mg, bound Mg, albumin, globulin, total protein, phosphate, pH and hematocrit. There are apparently significant disturbances of Ca2+ and Mg2+ during resuscitation from hemorrhagic shock. These disturbances may in part explain cellular dysfunctions during shock, including decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation and mitochondrial acidosis.

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