DISTRIBUTION AND ANTI-TUMOR ACTIVITY OF ADRIAMYCIN GIVEN IN A HIGH-DOSE AND A REPEATED LOW-DOSE SCHEDULE TO MICE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 62  (5) , 791-800
Abstract
Experimental studies on the distribution of adriamycin (AM) under different treatment conditions and possible correlations between tissue and plasma levels and chemotherapeutic activity are discussed. C57BL/6J mice bearing intramuscular Lewis lung carcinoma and (C3H g O2O)F1 mice bearing mammary carcinoma were injected i.v. with AM at a single dose of 15 mg/kg or with the same total amount of drug administered in spaced doses of 3.75 mg/kg for 4 days. In the 2 experimental systems studied, the drug reached approximately the same value in the tumor and spleen with both types of treatment, but with the 3.75-mg/kg g 4 schedule lower AM concentrations were observed in the heart than with the single high-dose treatment. The therapeutic activity of the 2 treatments also differed: the autitumor and antimetastatic effect was the same in the 2 tumor systems, but with the 3.75-mg/kg g 4 schedule, increased survival and somewhat lower toxicity were observed. Daunorubicin, tested in the mammary carcinoma system with the 3 schedules of treatment, behaves similarly to AM in terms of distribution and chemotherapeutic effects.

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