DIFFERENCES IN URINARY TRICHLOROETHYLENE METABOLITES OF ANIMALS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 33  (6) , 415-421
Abstract
Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloroetylene (1 mmol/kg) was injected i.p., then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats and rabbits. The ratio of total trichloroethanol to trichloroacetic acid in urine decreased in the order of rabbits (69.2), mice (12.8) and rats (2.3). The high ratio in rabbits was due to the extremely small amount of trichloroacetic acid in the urine. Differences in these 2 urinary metabolites in the 3 kinds of animals and in human subjects were discussed.