COMPARISON OF TC-99M LABELED LIVER AND LIVER PATE AS MARKERS FOR SOLID-PHASE GASTRIC-EMPTYING

  • 1 January 1984
    • journal article
    • research article
    • Vol. 25  (3) , 364-366
Abstract
A radionuclide marker for studies of solid-phase gastric emptying should have a high labeling efficiency and remain relatively stable during gastric emptying. The availability of materials and the ease of preparation are also considerations in selecting radionuclide markers. The stability of intracellularly labeled chicken liver, surface-labeled chicken liver and labeled pureed meat (liver pate) incubated with HCl solution or gastric juice. Intracellularly labeled chicken liver and labeled liver pate were also compared in gastric emptying studies in humans. In vitro results demonstrated labeling efficiencies greater than 92% for both intracellularly labeled liver and labeled liver pate. The pate labeled with Tc-99m sulfur colloid was more stable than Tc-99m surface-labeled liver in vitro and its preparation was easier than with the intracullular labeling technique. Gastric emptying studies on normal subjects demonstrated equal performance of the intracellularly labeled liver and the labeled liver pate. Labeled liver pate is an alternative to intracellularly labeled chicken liver in measuring solid-phase gastric emptying.