Persistent Hypertransaminasemia as the Presenting Finding of Childhood Muscle Disease
- 1 September 1985
- journal article
- other
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 24 (9) , 500-503
- https://doi.org/10.1177/000992288502400906
Abstract
Four children with isolated, persistent elevations of serum transaminases were investigated for hepatic disease and followed for 4 to 24 months before serum creatine kinase determinations were obtained and found to be markedly elevated. Evidence of muscle disease was obtained by close questioning, retrospectively, and mild abnormalities were found on physical examination. Review of laboratory tests in our center for 6 months revealed 30 additional cases of anicteric hypertransaminasemia (20% of those with elevated enzymes), only two of which were unexplained by the admitting diagnosis. Serum transaminase values are elevated in a variety of diseases of different organ systems. Creatine kinase determinations may provide the clue to the diagnosis of occult muscle disease in some children with unexplained anicteric hypertransaminasemia.Keywords
This publication has 5 references indexed in Scilit:
- The Enzymology of Skeletal Muscle DisordersCRC Critical Reviews in Clinical Laboratory Sciences, 1984
- Creatine kinase isoenzyme patterns in human tissue obtained at surgery.Clinical Chemistry, 1976
- Serum Enzyme Alterations in Neuromuscular DisordersJAMA, 1973
- Serum Glutamic Pyruvic Transaminase in Cardiac and Hepatic Disease.Experimental Biology and Medicine, 1956