Bilateral Fetal Grafts for Parkinson's Disease: 22 Months' Results
- 18 September 1992
- journal article
- Published by S. Karger AG in Stereotactic and Functional Neurosurgery
- Vol. 58 (1-4) , 84-87
- https://doi.org/10.1159/000098977
Abstract
Five patients with severe Parkinson''s disease underwent bilateral multiple graft implants of nondissociated fetal mesodiencephalic tissues. Graft implantation was performed in China following CT-guided stereotactic placement of a novel delivery system. Follow-up has demonstrated substantially reduced levodopa requirements and clinical improvements of motor, postural functions and reduction of freezing and on-off phenomenon. PET utilizing [18F]-dopa, at 14 months in the first case, suggested graft-induced restoration of dopaminergic transmission in the striatum.Keywords
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