CARDIOVASCULAR EFFECTS OF INTRAVENOUS ADMINISTRATION OF PROPYLENE-GLYCOL AND OF OXYTETRACYCLINE IN PROPYLENE-GLYCOL IN CALVES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (6) , 783-791
Abstract
Comparisons were made of the acute cardiovascular effects of oxytetracycline, oxytetracycline in propylene glycol and propylene glycol alone given to conscious dairy calves. The calves were chronically instrumented with i.v. catheters and electromagnetic flowmeter transducers in and on the pulmonary and renal arteries. Injection (i.v.) aqueous preparations of oxytetracycline produced no statistically significant (P > 0.05) cardiocirculatory changes in these calves. Oxytetracyclinein propylene glycol and propylene glycol alone produced transient (1-4 min) periods of cardiovascular depression characterized by cardiac asystole, systemic hypotension, and decreased pulmonary and renal arterial blood flow. The 2 preparations, in equivalent doses and volumes, produced statistically similar hemodynamic changes in the calves. The monitored cardiovascular effects of the commercially available oxytetracycline in propylene glycol in the intact, awake calves were due to the solvent propylene glycol.