Confluentic Acid and 2'-O-Methylperlatolic Acid, Monoamine Oxidase B Inhibitors in a Brazilian Plant, Himatanthus sucuuba.
- 1 January 1994
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 42 (6) , 1198-1201
- https://doi.org/10.1248/cpb.42.1198
Abstract
Monoamine oxidase B (MAO-B) inhibitors were isolated from the bark of a Brazilian plant, Himatanthus sucuuba (SPR.). Assignments of the 1H-and 13C-NMR data using two dimensional (2D)-NMR techniques showed the active components to be known lichen depsides, confluentic acid (1) and 2'-O-methylperlatolic acid (2). The depside (1) showed selective inhibition of MAO-B with IC50 value of 0.22μM.Keywords
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