Development of an Efficient, Regio- and Stereoselective Route to Libraries Based on the β-d-Glucose Scaffold
- 8 November 2000
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 65 (24) , 8307-8316
- https://doi.org/10.1021/jo001099v
Abstract
The design and execution of an efficient synthetic route for the sequential functionalization of the five hydroxyl substituents of β-d-glucose has been achieved. This strategy, based on the stereoselective glycosidation of thioglycosides, provides a new approach for the parallel construction of a wide variety of β-d-glucose analogues and as such holds promise for solid-support library syntheses.Keywords
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