Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

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Abstract
Five patients who had undergone radiation therapy for cerebral tumors and whose conditions were deteriorating were examined by means of positron emission tomography (PET) with [18F] fluorodeoxyglucose. All 5 cases had similar clinical and computed tomographic findings. Using the PET technique the 2 cases of radiation necrosis were distinguished from the 3 recurrent tumors. In the 2 cases of radiation necrosis, the rate of glucose utilization in the lesion was markedly reduced compared with the normal brain parenchyma. In the recurrent gliomas, however, the glucose metabolic rate was elevated. All 5 diagnoses were confirmed by biopsy or autopsy.

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