Chemical Debridement of the Burn Eschar in Rats with Bromelain Combined with Topical Antimicrobial Agents
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 11 (5) , 353-359
- https://doi.org/10.1159/000128084
Abstract
The necrolytic activity of bromelain was tested on 3rd degree burns in rats. Using a 35% concentration of the enzyme in a lipid base, complete and selective debridement was observed within 24 h. No general side effects due to systemic toxicity were observed. Histologically, local damage to the adjacent unburned tissue could be excluded. The combination of the enzyme with local antimicrobial agents did reveal complete inhibition of bromelain by PVP iodine, whereas no significant decrease of the enzymatic effectivity was caused by 1% silver sulfadiazine or 1% gentamycin.Keywords
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