Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes
- 15 June 1992
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 284 (3) , 649-652
- https://doi.org/10.1042/bj2840649
Abstract
Physiological concentrations of growth hormone induced a rapid and transient activation of mitogen-activated protein kinase (MAP kinase) and S6 kinase in 3T3-F442A preadipocytes. These effects were abrogated by staurosporine and in cells chronically pretreated with phorbol esters, suggesting that protein kinase C is involved in the mechanism of activation. In addition, three cytosolic proteins exhibited a growth-hormone-dependent increase in tyrosine phosphorylation.Keywords
This publication has 33 references indexed in Scilit:
- Rapid Events in Growth Hormone Action. Induction of c-fos and c-jun Transcription in 3T3-F442A Preadipocytes*Endocrinology, 1990
- Growth Hormone (GH) Stimulates Protein Synthesis in Cells Transfected with GH Receptor Complementary DNAMolecular Endocrinology, 1990
- Identical Mr 70,000 S6 kinase is activated biphasically by epidermal growth factor: a phosphopeptide that characterizes the late phase.Proceedings of the National Academy of Sciences, 1990
- Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.Proceedings of the National Academy of Sciences, 1989
- Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteinsBiochemical Journal, 1988
- Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase IINature, 1988
- Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.The Journal of cell biology, 1988
- Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytesBiochemistry, 1988
- Growth hormone regulation of the expression of differentiation-dependent genes in preadipocyte Ob1771 cellsBiochemical Journal, 1986
- A dual effector theory of growth-hormone actionDifferentiation, 1985