Reactions of K2PtCl4 with pyridine derivatives in dimethylformamide and synthesis of potassium trichloro(pyridine)platinum(II)
- 15 February 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 56 (4) , 441-445
- https://doi.org/10.1139/v78-070
Abstract
The reactions of K2PtCl4 with pyridine derivatives L (L = py = pyridine, pic = picoline, and lut = lutidine) were studied in dimethylformamide (DMF). .**GRAPHIC**. The [antitumor] complexes were isolated and the yield decreased with the order, 2,4-lut = 2-pic > 2,6-lut > 4-pic = py, which can be correlated to the steric hindrance of the o-methyl groups. The compounds can be converted, the free ligand acting as catalyst, to the final product of the above reactions. The compounds can also be obtained from a DMF solution of [Pt(L)4]Cl2 (L = py) at room temperature. A comparison of the above reactions in water and in DMF was also made.Keywords
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