THE PROTECTIVE ACTION OF FLUOCORTIN BUTYLESTER (FCB) IN THE NASAL ANTIGEN PROVOCATION TEST - A CONTROLLED DOUBLE-BLIND, CROSSOVER STUDY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 48  (5) , 305-308
Abstract
Fluocortin butylester (FCB), a locally active corticosteroid, was inhaled as a fine powder mixed with lactose using the rhinolator in a comparative double-blind, crossover study against placebo. Fifty patients of both sexes aged 16-46 yr with an established seasonal allergic rhinitis, but free of symptoms, took part in this trial. The determination of the protective action after allergen provocation was performed after 7 days treatment with 4 mg FCB or placebo. Measurements of the nasal resistance and the temperature were taken after provocation. The symptoms of nose and eyes were recorded. The protective effect of FCB against provocation with grass pollen extracts was statistically proved.

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