Bone marrow transplantation and chemical protection in the radiotherapy of mouse leukemia

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Abstract
Attempts were made to extend the radiation induced survival of mice, bearing transplanted lymphomas, by the use of isologous bone marrow or the radioprotective chemical agent, aminoethylisothiuronium-Br HBr (AET). Increased amounts of radiation tolerated by virtue of post-treatment with isologous bone marrow prolonged survival beyond that obtainable with sublethal doses of roentgen rays alone. Increased amounts of radiation tolerated by virtue of pretreatment with AET also further prolonged survival in one of two transplanted lymphomas studied, which suggests that in this instance normal tissues received greater protection than the lymphoma. Fractionated or protracted irradiation was not significantly more effective than a single brief exposure under the conditions tested.

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