Long‐term immune reactivity to pre‐S(2)‐antigen after acute hepatitis B infection
- 1 February 1989
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 27 (2) , 95-99
- https://doi.org/10.1002/jmv.1890270205
Abstract
We investigated sera from 39 patients, taken 1-8 years after recovery from acute hepatitis B for anti-pre-S(2) by Western blotting and for anti-HBs by radioimmunoassay. Anti-pre-S(2) antibodies were found in 27 out of 39 sera (69%) with the highest frequency in sera with anti-HBs > 100 IU/l (92%). However, sometimes sera with low anti-HBs titers showed a strong response in Western blotting. Acute hepatitis sera were also investigated from a limited number of patients (n = 14). Anti-pre-S(2) antibodies were found during antigenaemia (four out of six patients) and within 3 months after the maximum of alanine amino transferase (ALAT) (seven out of ten patients). Anti-pre-S(2) is an early antibody. It remains in the circulation for many years similar to but independent of anti-HBs.This publication has 13 references indexed in Scilit:
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