Systemic Bone Marrow Disorders
- 1 July 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Computer Assisted Tomography
- Vol. 14 (4) , 633-642
- https://doi.org/10.1097/00004728-199007000-00023
Abstract
In a prospective clinical study, 26 patients (22 with malignant lymphoma and 4 with myelofibrosis) and 9 healthy volunteers were examined by conventional magnetic resonance and proton chemical shift imaging (CSI; modified Dixon method). On the basis of the CSI data, a quantitative evaluation of the relative fat and water signal fractions in regions of interest of the femur, pelvis, and spine was performed. In 16 of 17 patients with biopsy-proven bone marrow disorders, CSI revealed a significant reduction in the fat fraction of the bone marrow relative to that of normal volunteers. The visual assessment could detect only 14 of the 17 pathological cases.Keywords
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