Effects of Continuous Light and Darkness, and of Pinealectomy, Adrenalectomy and Gonadectomy on Uptake of 3H-Serotonin by the Suprachiasmatic Nuclear Region of Male Rats
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 22 (3) , 231-239
- https://doi.org/10.1159/000122630
Abstract
Rats exposed to continuous light show no significant differences in serotonin (5-HT) uptake by the suprachiasmatic nuclear region (SNR) at 10.00 and 22.00 L, while in continuous darkness, the uptake at 10.00 D is significantly higher than uptake at 22.00 D. In consideration of the role of the suprachiasmatic nucleus in light-mediated control of neuroendocrine activity, this suggests endogenous generation or control of this uptake rhythm. An effect of sham-pinealectomy in decreasing 5-HT uptake was found, but cannot be fully interpreted at this time. The lack of effect of castration or adrenalectomy suggests that these endocrines have little if any direct effect on 5-HT mechanisms in the SNR.Keywords
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