p-Anisaldehyde-Thiosemicarbazone in Treatment of Experimental Murine Tuberculosis.
- 1 July 1950
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 74 (3) , 595-596
- https://doi.org/10.3181/00379727-74-17985
Abstract
Summary 1. One mg% of p-anisalde-hyde-thiosemicarbazone inhibits the growth of the H37RV and B1 strains of Mycobacterium tuberculosis in Dubos' medium. 2. Mice infected with the H37RV strain and fed 1% p-anisaldehyde-thiosemicarbazone in their diet had no gross tuberculosis when sacrificed at the end of 30 days, when all controls were dead of the disease. Infected mice, sacrificed after 75 days of treatment with p-anisaldehyde-thiosemicarbazone, showed only one plus gross pulmonary tuberculosis. 3. It may be concluded that p-anisalde-hyde-thiosemicarbazone is an effective anti-mycobacterial agent in the mouse as well as in vitro. We extend our appreciation to the Nepera Chemical Co., Inc., for supplying the drug, and to Dr. Charles J. Duca for conducting the in vitro work.Keywords
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- p-Anisaldehyde-Thiosemicarbazone in Treatment of Experimental Murine Tuberculosis.Experimental Biology and Medicine, 1950