Temocillin in peripheral lymph

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Abstract
One gram of temocillin was given intravenously to five healthy volunteers to study the concentrations in serum and peripheral lymph obtained by cannulation of the lower leg. The 1 h serum level was 58.1 mg/1 and the lymph level 14.3 mg/1. The mean peak lymph concentration was 30.6 mg/1 and occurred between 1.5 and 2 h; the simultaneous serum level was 47.8 mg/1. The antibiotic levels in lymph were always below those in serum. The urinary recovery over 12 h was nearly 60%. The mean ratio between the areas under the concentration curves of lymph and serum was 0.558. The serum half-life was 4.9 h, the apparent β-phase distribution volume 18.41. In comparison, the lymph half-life was 4.4 h. Protein binding appears to be of little consequence to the ability of temocillin to penetrate well into extravascular foci.

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