HEART AND KIDNEY INVOLVEMENT DURING ANTIHYPERTENSIVE TREATMENT - RESULTS FROM THE PRIMARY PREVENTIVE TRIAL IN GOTEBORG, SWEDEN

  • 1 January 1984
    • journal article
    • research article
    • Vol. 215  (4) , 305-311
Abstract
The prevalence of signs of heart (Minnesota-coded ECG, chest X-ray) and kidney involvement (proteinuria, abnormal serum creatinine) was studied before and after 5 yr antihypertensive treatment in 686 middle-aged, hypertensive men derived from a screening examination of a random population sample. The prevalences of heart enlargement (X-ray) and abnormally high serum creatinine increased. A pronounced regression of S-T and T wave changes in the ECG was achieved. In a subgroup of 375 patients without digitalis therapy and not having had myocardial infarction, ECG signs of left ventricular hypertrophy decreased.