Hippocampal Lesions Following Administration of 3-Acetylpyridine

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Abstract
Administration of single intraperitoneal LD50 dose of 3-acetylpyridine to non-inbred mice results in partial to complete destruction of hippocampal neurons in area H3 of the Vogts (areas CA3 and CA4 of Lorente de No). Fifteen of 20 mice sacrificed at intervals up to 2 months showed lesions in this area. In some, damage was irregularly present in other areas of hippocampus and in dentate gyrus, but not elsewhere in the brain.